Spanish Explorers By xxuncmanxx Jan 1, 1492 King and Queen agree to found Christopher Columbus's voyage Nov 22, 1492 Columbus begins his 3rd voyage. Mar 5, 1493 Christopher Columbus arives at spain bringing news about the New World. Oct 27, 1493 Columbus begins his second voyage. Jun 25, 1494 Columbus again returns to spain. May 25, 1519 Francisco Pizarro is mayor of Panama. Sep 26, 1523 Pizarro steps down from being mayor. Sep 26, 1523 Pizarro starts his first expedition to South America. Sep 26, 1526 Piarro starts second voyage. Sep 26, 1541 Pizarro was assasinated.