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Quinine first purified from tree bark. For many years prior, the ground bark had been used to treat malaria.
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Charles Louis Alphonse Laveran first identifies the malaria parasite. He is awarded the 1907 Nobel Prize for the discovery.
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Sir Ronald Ross demonstrates that mosquitoes transmit malaria. He wins the 1902 Nobel Prize for this work.
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Hans Andersag in Germany discovers the Anti-malarial drug Chloroquine, which is not widely used until after World War II.
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Paul Hermann Muller in Switzerland tests the insecticide DDT. He wins the Nobel Prize for this work in 1948.
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Malaria is eliminated in the United States.
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World Health Organization (WHO) launches Global Malaria Eradication Campaign, which excludes sub-Saharan Africa and is eventually abandoned.
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First documented case of resistance to Chloroquine is reported.
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William Trager and JB Jensen grow parasite in culture for the first time, opening the way for drug discovery and vaccine research.
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The U.S. Food and Drug Administration approves the use of the anti-malaria drug Mefloquine hydrochloride, registered as Lariam® by Hoffman-LaRoche.
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Malaria vaccine candidate RTS,S, developed by Glaxo Smith Kline and the Walter Reed Army Institute of Research, enters clinical trials.
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Insecticide-treated bednets are proven to reduce overall childhood mortality by 20 percent in large, multi-country African study.
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Roll Back Malaria Partnership (RBM) launched by WHO, UNICEF, UNDP and World Bank with goal of halving malaria incidence and mortality by 2010.
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WHO adopts home management strategy for malaria whereby trained community volunteers provide anti-malarials in remote African communities.
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The U.N. General Assembly adopts the Millennium Development Goals, setting a target to halt and begin reversing malaria incidence by 2015.
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WHO prequalifies first fixed-dose Artemisinin combination therapy (ACT), sold by Novartis as Coartem® and recommends ACT as first-line malaria treatment.
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Genome sequencing of Anopheles gambiae (mosquito) and Plasmodium falciparum (parasite) completed.
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World Health Assembly adopts target of 80 percent worldwide coverage of insecticide nets and ACTs by 2010.
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UCSF study shows combination malaria therapy effective in treating African children
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The Global Health Group at UCSF comes forward with the first high-level strategy for the eventual achievement of malaria eradication. This strategy has since been widely adopted.
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Representatives of nations around the world meet in New York and endorse the Global Malaria Action Plan (GMAP), which lays out a vision for reducing malaria in the short term and eventually eradicating it when new tools become available.
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United Nations adopt April 25 as World Malaria Day.
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UCSF experts outline new strategy to eliminate malaria
