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He set sail with Pedrarias to Panama
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De Soto takes part in the conquest of Nicaragua.
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He sailed under the leadership of Spaniard Fransisco Pizarro in 1530, and returned to Spain in 1534
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De Soto returned back to the Americas and by May 1539 had reached the West coast of Florida.
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Was given credit for being the first European to find the Mississippi River, near Memphis, Tennessee.
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He died of a fever on the banks of the Mississippi River, and was buried in the River, so the Native Americans who he fought with didn't discover he died.