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Columbus claims Hispaniola to be Spain and sights to Cuba referring to it as, Japan.
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Balboa sailed across the Isthmus of Panama and discovers the Pacific Ocean.
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Hernan Cortes invades Mexico in 1519 and conquers the Aztec empire at Tenochtitlan.
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Conquistador Hernando de Soto and his men become the first Europeans to discover the Mississippi river and cross it.
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The Jamestown settlement is the first English settlement founded in Jamestown Virginia by the Virginia company of London.
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Plymouth Colony was the first colony settlement in New England.
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The last major move by the Native Americans to force the English settlers out, they fail.
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Robert Cavelier Sieur de La Salle, claims the Mississippi River valley and names it Louisiana in honour of his king.
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