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Protests in response to the Killing of Eric Garner. Twitter was the most used and the hashtag #ICantBreathe was trending.
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In October 2017, after many sexual abuse allegations of a high profile film producer were exposed, Alyssa Milano took to Twitter and said "If all the women who have been sexually harassed or assaulted wrote 'Me too' as a status, we might give people a sense of the magnitude of the problem." From there, other celebrities shared their experience, then it continued to the masses. Most of this was shared via Twitter than later spread to Instagram.
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A protest march was organized and demonstrated by students in response to the shooting at Stoneman Douglas High School, in which multiple people were killed. Twitter was the first social media used, some students even giving live updates during the incident. But attention to the cause was later picked up on Instagram after celebrities starting using the hashtag #MarchForOurLives
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This incident was when leaked messages by the governor of Puerto Rico and his cabinet were exposed, as the nature of the messages were vulgar, homophobic, and racist. There was a huge protest in person shutting down a huge highway and also protesting online that was primarily via Twitter with the hashtag #RickyRenuncia, wanting the governor to resign.
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Protests in response to the killing of George Floyd at the hands of police officers in 2020. The hashtag #BlackLivesMatter had been around for years before, but this incident really catapulted this subject to the masses. This hashtag and subject was viral among all platforms, especially Twitter, then Instagram and Facebook afterwards.