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If in 1275 Ramon Llull had not experimented with chemicals, they would subsequently discovered anesthesia.
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If in the sixteenth century Swiss physician Paracelsus had not studied chickens anesthetic substances (unknowingly), no human had tried anesthesia.
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If Horace Wells had not used anesthesia in dentistry, would not be used today
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If John Collins Warren had not used anesthesia in tumor surgery, general anesthesia would not be used.
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If in 1846 the Edinburgh hospital anesthesia had not established its operations, other hospitals would not have set in their surgeries.
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If you had not used anesthesia for medical operations, patients would have pain in procedures.
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If anesthesia was not used in dentistry, dental extractions would be painful.