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Columbus lands at Hispaniola in the Caribbean.
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Balboa "discovers" the Pacific Ocean in Panama.
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Cortes conquers the Aztecs at Tenochtitlan (Mexico City).
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De Soto explores the region between Florida and the Mississippi River.
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First permanent English settlement is founded in Jamestown, Virginia.
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Mayflower Pilgrims found Plymouth colony in Massachusetts.
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English settlers defeat Native Americans in King Philip's War.
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France claims the Mississippi River Valley and names it Louisiana.
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