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Columbus was born in present day Italy.
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Columbus set out to find a new route for India, but instead found America, though he didn't know it. He spent all of his life thinking that he discovered a new route to INDIA.
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Columbus diedat age 54, still thinking that America was India.
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The epidemic of Small pox cilled 30% of the native American population. It is diseases like this that brought down the native American population.
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Vaccine
Though this vaccine was made, the native Americans did not trust the Europeans to administrate it.