Christopher Columbus's Expeditions By facebooker_1079631948 Aug 3, 1492 Columbus set sail from Palos, Spain. Period: Aug 3, 1492 to Nov 7, 1504 Christopher Columbus's Expeditions Oct 11, 1492 Landed in Guanahani, but renamed San Salvador Mar 15, 1493 Returned to Spain Sep 25, 1493 Set sail on second voyage Nov 3, 1493 Spotted and named the island of Dominica Jun 11, 1496 Returned to Spain from second voyage May 30, 1498 Began third expedition and sailed farther South to Trinidad and Venezuela. Oct 1, 1500 Third voyage ended Exact date is unknown. May 9, 1502 Fourth and final voyage, sailed to Mexico, Honduras, Panama, and Santiago (Jamaica) Nov 7, 1504 Last day of voyage