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In Columbus's voyages, a great interaction between the 'New World' and 'Old World' took place. This Interaction is sometimes referred to as the Columbian Exchange
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In 1498 Columbus reached South America
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In 1524 King Francis I of France sent Italian navigator Giovanni da Verrazano wetsward.
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In 1524 King Francis 1 of France sent Italian navigator Giovanni da Verrazano westward. Verrazano first reached land at North Carolina's Outer Banks.
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In July 1526, Ayllon led a group of over 500 men, women, and children to a river called 'Jordan' (for the Jordan River in ancient palestine).
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In 1942 Columbus led his first expedition westward. He landed in the bahamas, islands that he believed to be near Asia.