Christopher Columbus By henjolis Oct 31, 1451 Christopher Columbus was born in Genoa Period: Oct 31, 1451 to May 20, 1506 Christopher Columbus Aug 3, 1492 Columbus departs for his first voyage. Oct 12, 1492 Land was spotted by Rodrigo de Triana Sep 24, 1493 Columbus leaves for his second voyage. Dec 8, 1493 Columbus founds a new colony, La Isabela. May 30, 1498 Columbus departs with six ships, to his third voyage. Aug 11, 1500 Columbus was arrested and sent back home in chains. May 11, 1502 He departs from Cadiz, Spain for his fourth voyage. Nov 7, 1504 Columbus returns to Spain after his final voyage. May 20, 1506 Columbus dies in Valladolid.