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Eli Whitney invents the cotton gin, a machine which revolutionized the South, cotton production, and cemented slavery.
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U.S. Supreme Court gains right to judicial review.
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President Jefferson buys land in the Westward United States from Napoleon for $15 million.
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After increasing tensions between the new America and Britain over the seizing of American navy men and the natives stockpiling weapons, a war broke out.
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President Monroe issues an ultimatum forbidding further colonization of the western hemisphere by European powers.
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New York State completes the Erie Canal.
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A bloody civil war between the Northern and Southern United States. Costliest war in U.S. history.