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The Susan Constant, the Discovery, and the Godspeed land in Jamestown, Virginia and establish the first colony.
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Pocahontas marries John Rolfe and brings peace among the colonists and Indians. Tobacco seeds are also brought to the colony.
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An epidemic of smallpox kills 90% of the Native Americans living near Massachusetts Bay.
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The Mayflower Compact is made and the Puritans settle in Plymouth.
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The first Thanksgiving celebration takes place between the pilgrims in Plymouth and the Wampanoag tribe.
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The first college in the United States was established in Cambridge, Massachusetts.
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Connecticut legalizes slavery and it becomes recognized among the colonies.
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The British take control of commerce in the New World.
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War between the colonists in New England and Metacom led Indians breaks out.
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The French claim Louisiana through Robert Cavalier's exploration.
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150 people were arrested and 19 killed in the Salem which hunts.