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The lively realism of Kamal-ud-din Bihzad lays the basis of both the Persian and the Mughal schools of painting. (Exact Date Unknown)
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Michelangelo begins work in Florence on a tall thin slab of marble, which he transforms into David. (Exact Date Unknown)
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Italian navigator Amerigo Vespucci sets sail from Lisbon to explore to the south of the New World. (Exact Date Unknown)
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The Portuguese set up a trading post on the east African island of Zanzibar. (Exact Date Unknown)
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The Portuguese establish a presence in Sri Lanka, trading in the island's crop of cinammon. (Exact Date Unknown)
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Leonardo captures the enigmatic smile of Lisa Gherardini, known now as the Mona Lisa. (Exact Date Unknown)
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John Calvin, French theologian. He started the Protestant Reformation in France in 1532. (Exact Dates Unknown)
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Leonardo da Vinci designed the horizontal water wheel that was the forerunner of the modern water turbine. (Exact Date Unknown)
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In Mecca, Arabia, there was an attempt to ban coffee
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One surviving ship of Magellan's fleet, the Victoria, returns to Sanlucar, in Spain, with Sebastian Cano in command. (Exact Date Unknown)
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John Calvin, French theologian, started Protestant Reformation in France.