1500-1600 By acesusap Jan 1, 1500 High point of Renaissance High point of Renasissance Mar 27, 1513 Juan Ponce de Leon lands in Flordia Jan 1, 1516 smallpox introduced to the "New World" Apr 21, 1519 Hernan Cortes landed in Mexico May 10, 1534 James Cartier explores the St. Lawrence River May 18, 1539 Hernando de Soto and Vasquez de Coronado expeditions Jan 1, 1550 Tobacco introduced into Europe Jan 1, 1558 Elizabeth I of England begins her reign Nov 27, 1562 Huguenot colony planted along mid-Atlantic coast Jul 22, 1584 Walter Raleigh's colony on Roanoke Island Jul 27, 1588 English defeat the Spanish armada Jul 11, 1590 John Wright returns to find Roanoke Island abandoned Nov 28, 1598 Juan de Onate leads Spanish into Mexico