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The London Company established the Colony of Virginia as the first permanent New World English colony.
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A group of 20 African slaves arrived in Jamestown on a Dutch ship. http://en.wikipedia.org/wiki/History_of_slavery_in_Virginia
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After being driven from Massachusetts, Clergyman Thomas Hooker and his followers arrived in Hartford, CT and declared freedom from all save Divine Authority.
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South Carolina becomes the first European settlement in North America.
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The village of Jamestown was nearly destroyed during "Bacon's Rebellion". http://phyllisdoyle.hubpages.com/hub/Bacons-Rebellion-of-1676-Jamestown-Colony
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Georgia is established as the last of the original Thirteen Colonies.
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Charles Mason and Jeremiah Dixon, two young British astronomers commissioned to establish a borderline between Maryland and Pennsylvania, worked for more than four years to settle a century-old boundary dispute between the Calverts of Maryland and the Penns of Pennsylvania by establishing the Mason-Dixon Line.
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Trouble escalates over the tea tax, as Americans in each colony boycott the tea and in Boston, dumped the tea in the harbor during the Boston Tea Party.
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All royal officials had been expelled from all 13 colonies and the American Revolutionary War begins.
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Delegates from the 13 colonies unanimously issued the Declaration of Independence. It declared independence from Great Britain and formed a new sovereign state, the United States of America.