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Johannes Guten Berg invented the printing press.
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GutenBerg bible was printed by Johannes Butenberg with his printer
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Da Vinci finished the last supper
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Michelangelo finished the cieling of the sistive chapel
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Martin Luther passes his 95 theser in Wittenberg
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Da vinci finished the Mona Lisa
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In 1557, the = sign first used by Robert Records.
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The first microscope was invented by Zacharias Janssen and his father.
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In 1631, >,< was introduced by Thomas Harriot.