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Though slaves had likely existed before this time, the first record of African slavery in the British American colonies occurs in 1619.
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Demand for slave labor greatly increases.
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Though importation of new slaves was banned, the slave market was kept alive through reproduction.
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Slavery is banned in all territories north of the southern border of Missouri.
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Nat Turner organizes a slave rebellion that results in 56 white deaths, punishment of hundreds of black slaves in retaliation, and stricter Virginia slave laws
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Harriet Beecher Stowe publishes Uncle Tom's Cabin, a large factor in stirring support for the anti-slavery movement.
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The Supreme Court rules that Congress does not have the power to ban slavery in states, and that slaves are not citizens.
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Several states decide to secede from the United States of America to form the Confederate States of America, with one of their reasons being to maintain slavery in their states.
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President Abraham Lincoln issues the Emancipation Proclamation, stating that all slaves in the Confederacy shall be set free.
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The Thirteenth Amendment to the U.S. Constitution is adopted, prohibiting slavery and involuntary servitude.