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1519 - Panama becomes Spanish Vice-royalty of New Andalucia (later New Granada).
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1502 - Spanish explorer Rodrigo de Bastidas visits Panama, which was home to Cuna, Choco, Guaymi and other indigenous peoples
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1821 - Panama becomes independent of Spain, but joins the confederacy of Gran Colombia, which also comprises Colombia, Venezuela, Ecuador, Peru and Bolivia.
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1830 - Panama becomes part of Colombia following the collapse of Gran Colombia.
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1846 - Panama signs treaty with US allowing it to build a railway across the isthmus
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1880s - France attempts to build a canal linking the Atlantic and Pacific oceans, but fails due to financial difficulties and the death of more than 20,000 workers from tropical diseases.
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1903 - Panama splits from Colombia and becomes fully independent. US buys rights to build Panama Canal and is given control of the Canal Zone in perpetuity.
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1914 - Panama Canal completed
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1939 - Panama ceases to be a US protectorate.
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1968-81 - General Omar Torrijos Herrera, the National Guard chief, overthrows the elected president and imposes a dictatorship.