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1502 Columbus sails on his fourth and last voyage to the New World (Honduras and Panama)
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1,500 Spanish settlers travel to Panama in 1514
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Overthrow of the king of Spain by Napoleon
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Panama gained there independence.
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Panama becomes part of Colombia following the collapse of Gran Colombia
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The building of the Panama canal was done in this time span.
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November 3 - Panama splits from Colombia and becomes fully independent US buys rights to build Panama Canal and controls the waterway for nearly a centry
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1 January Control of the canal passes from USA to Panama by the Torrijos-Carter treaty