Insulin Changes from 1900-2012 By MirandaVascil238 Period: Jan 1, 1900 to Apr 16, 2012 Insulin Changes from 1900-2012 Jan 1, 1921 4 Canadian Scientists discovered insulin Feb 1, 1923 Banting and Macleod were awarded the Nobel Prize Jan 1, 1936 Protamine was made to develop a slow-release insulin Jan 1, 1950 Isophane IPH insulin was created to bind with Protamine Jan 1, 1951 Amorphous ‘lente’ insulins (IZS) was developed to be used without Protamine Jan 1, 1956 The first antidiabetic oral drugs were developed Jan 1, 1963 Human insulin was chemically synthesized in Germany Jan 1, 1974 Chromatographic purification techniques allowed the production of purified animal insulin Jan 1, 1975 Fully synthetic insulin was synthesized in a laboratory in Basel Jan 1, 1978 Scientists succeeded in producing insulin with the same amino sequence as seen in humans Jan 1, 1980 Recombinant DNA human insulin was first tested on 17 nondiabetic volunteers in England Jan 1, 1982 The FDA approved Humulin R (rapid) and Humulin N (NPH) for the US market Jan 1, 1996 Different insulins are being introduced worldwide