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Biologist Rudolf Jaenisch creates the first genetically modified animal, a transgenic mouse, by introducing foreign DNA into its embryo. (source)
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The U.S. Food and Drug Administration approves the first genetically engineered drug Humulin, a form of human insulin produced by recombinant E. coli bacteria. Prior to the development of synthesized human insulin, patients were dependent on animal insulin, which was more costly, less accessible, and sometimes caused infection. Humulin is identical in chemical structure to human insulin. (source, source)
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The first field tests of genetically engineered (tobacco) plants are conducted in Belgium. (source)
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The first field tests of genetically engineered (tobacco and tomato) crops are conducted in the United States. (source)
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The U.S. Department of Agriculture approves the Flavr Savr tomato, intended to be resistant to softening and consequent rotting, as the first genetically engineered food to be granted a license for human consumption. Production ceased in 1997 due to poor crop turnaround and mounting costs. (source, source)
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The FDA declares that genetically engineered foods are “not inherently dangerous” and do not require special safety testing or specific regulation, because they are alike and more aligned with the category of “whole foods”, which the FDA does not oversee, rather than “food products.” (source, source)
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The European Union’s first genetically engineered crop, tobacco, is approved for use in France. (source)
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The EU imposes an unofficial ban on GMO-based products, refusing to engage in experimental or commercial growth of new gene crops and to import GM food products. The World Trade Organization is currently due to rule if this unofficial ban restricted trade. (source)
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Australia, the Czech Republic, Hong Kong, and Russia pass laws requiring labels for GM foods. (source)
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The EU adopts regulation that even additives and flavoring must be specifically labeled if DNA or protein of GMO origin is present in the final product. (source)
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Japan, South Korea, and Taiwan follow suit and also pass laws requiring special labels for GM foods. (source)
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GloFish, a GM fluorescent fish first developed in 1999, is introduce to the U.S. market after being available in Taiwan earlier in 2003. Since their introduction, there have been no reports of any ecological concerns associated with their sale, though they are illegal in California due to a regulation that bans all genetically modified fish. They are also banned in Canada and within the EU. (source)