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Isolated the genetic material from white blood cell nucleui. He noted it had an acidic nature and called it nuclein
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Determined the components of DNA:
adenine, guanine, thymine, cytosine, deoxyribose phosphate
defined phosphatus-sugar base units called nucleotides. -
Griffith used two strains of Streptococcus:
Type S: virulent (deadly)
Type R: non-virulent (harmless) -
Determined the cause of the transformation in Griffith's experiment.
They took live R and heat-treated S and mixed it with one of two enzymes. -
Used paper chromatography and UV spectroscopy to examine the abundance of the nucleobases and he started to notice something VERY odd...
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This prize was for Francis Crick, James Watson and Maurice Wilkins, for their discoveries concerning the molecular structure of nucleic acids and its significance for information transfer in living material.