Dna Replication By MadisonHarris1 1950 STEP 1 Helicase" Unzipping" enzyme, it unzips the 2 strands of DNA. Comes in and unwinds the DNA 1950 Step 2 Primase makes primer so that DNA polymerase knows where to work 1950 Step 3 Ligase is like glue it help DNA fragments stay together.