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Francisco Pizarro made his first voyage to the New World in November 1524. He returned to Spain with empty hands.
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Pizarro's second voyage (November 1526 to late 1527) was much larger, with 160 men and several horses carried in two ships
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Pizarro and his men set sail for Colombia and Ecuador. Accompanied by Ruiz and his Indian interpreters. They encountered more balsa rafts. They sailed on until the Indians recognized the coast of their hometown, Tumbes. The Spanish anchored near the little port known today as Puerto Pizarro.
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Pizarro returned elated to Panama and, there, the partners formulated their plan of conquest. He then took a ship to Spain, seeking backers and royal approval.
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According to the Inca account, dictated later by the King's nephew, Titu Cusi, there was an immediate failure of communication over the traditional guest rituals of Andean diplomacy.
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Pizarro returned to Tumbes to find it in ruins — a burned-out, ransacked victim of the civil war raging in the empire. Pizarro and his small army marched into the interior
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Friar Vicente explained that the Spanish ruler was a friend of God and called upon the Inca to renounce their gods. Atahuallpa asked Friar Vicente what authority he had for his belief, and the friar told him it was all written in the book he was holding. The Inca then said: Give me the book so that it can speak to me
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Atahuallpa's motive says Waman Poma "was to free himself by paying them gold." If he paid up, he believed they would go away. It never seems to have occurred to him that these few — fewer than 200 — might be the precursors of thousands, who would come to settle permanently in his land, and that one payment of gold would not be enough.
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When it came time for Pizarro to fulfill his side of the bargain and release Atahuallpa, news came from Quito that one of the Inca's generals had assassinated Huascar. Pizarro accused Atahuallpa of plotting against him, and put him on trial for treason.