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  Japan’s first contact with Christianity is 1549
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  Dominican Gaspar da Cruz arrives in Guangzhou, China
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  Jesuits begin mission work in China, introduce Western science, mathematics, astronomy
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  Matteo Ricci and a Chinese scholar translate a catechism into Chinese under the title T'ien-chu sheng-chiao shih-lu (A True Account of God and the Sacred Religion)
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  Carmelite leader Jerome Gracian meets with Martin Ignatius de Loyola, a Franciscan missionary from China. The two sign a vinculo de hermandad misionera -- a bond of missionary brotherhood -- by which the two orders would collaborate in missionary work in Ethiopia, China, the Philippines, and the East and West Indies
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  The Franciscans arrive in Japan and establish St. Anna's hospital in Kyoto
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  Jesuit missionaries travel across the island of Samar in the Philippines to establish mission centers on the eastern side
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  Twenty-six Japanese Christians are crucified for their faith by General Toyotomi Hideyoshi in Nagasaki, Japan. By 1640, thousands of Japanese Christians will have been martyred
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  Matteo Ricci goes to China; First ordination of Japanese priests
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