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The Columbian Exchange vertualy started when Columbus and his men traided with the natives to America. Because of the Exchange things like Turkeys and potateos were braught to Europe and things like Diseases and Coffee were braught to the Americas.
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Cortes and his men leave Tenochtitlan and keep moving until they are excepted peacefuly by Montazuma and the entire Aztec Empire
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A series of Hatian Slave rebelions led by Toussaint Louverture.
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Hiram Bingham discovers Mahcu Picchu while looking for the hiden Incan fortress vilcabamba.