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The first permanent English settlement is founded.
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The House of Burgesses, the first representative assembly in America, meets for the first time in Virginia.
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Slaves are brought to America.
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The Mayflower Compact is signed.
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The Plymouth Colony in Massachusetts is established.
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New Amsterdam is founded later to be named New York.
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The colony of Massachusetts Bay is founded.
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The Province of Maryland is founded.
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The colony of Connecticut is founded.
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The colony of Rhode Island is established.
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The colony of New Haven is established.
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The Delaware Colony is founded.
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The Beaver Wars, AKA the French and Iroquois Wars escalate.
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The Anglo-Powhatan Wars were three wars fought between settlers of the Virginia Colony and Algonquin Indians of the Powhatan Confederacy.
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The Maryland Toleration Act, also known as the Act Concerning Religion, was a law mandating religious tolerance for Trinitarian Christians.
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The Peach Tree war was a large-scale attack by the Susquehannock Indians and allied tribes on several New Netherland settlements along the Hudson River in New York.
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The Esopus Wars were two conflicts between the Esopus tribe of Lenape Indians (Delaware) and New Netherlander colonists.
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Charles Town is founded.