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  Johannes Gutenberg finishes his printer, books are now available for everyone.
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  Gutenberg bible was printed by Johannes Gutenberg with his printer.
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  Donatello finishes his painting, Judith and Holofernes.
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  Lerenzo de Medici rules most of florence, indirectly.
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  Leonardo da Vinci's painting, The Last Supper is finished.
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  The innovative Italians of the Renaissance are widely acknowledged to be the fathers of modern accounting.
14th - 16th century - 
  
  Michelangelo completes his sculpture, David.
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  Martin Luther passes his 95 theses in Wittenberg
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  Copernicus discovers that the planets revolve around the sun, instead of them all revolving around Earth. It is published in a book in 1543, when he died.
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  The = sign first used by Robert Record.
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  Jost Burgi invents minute hand clock for an astronomer.
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  Galileo discovers the pendulum clock.
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  Zacharias Janssen invents the microscope with his father.
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  Hans Lippershey, a Dutch lensmaker, invents the telescope.
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  Thomas Harriot introduces the > and < symbols.