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The Ottomans defeat the Mamluks in Egypt in 1517. This gives the Ottomans access to more trade. It also begins to give the Ottomans influence in the area, and it begins to open up access to the Red Sea
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The Ottomans take Baghdad. This continues to give the Ottomans influence in the area, and continues to open up the Red Sea trade route
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The Ottomans take the Habesh Eyalet, located on the coast of the Red Sea. This granted the Ottomans access to the Red Sea spice trade, and this gave the Ottomans loads of money. It also blocked Portuguese influence in the area and gave them full control of the coast.