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In his highly influential Sidereal Messenger, Galileo Galilei publishes his telescopic findings with subtle Copernican twists. Among his observations, Galileo argues there are innumerable stars invisible to the naked eye, mountains on the Moon and four moons circling Jupiter.
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Galileo's second major book, the Discours on Two New Sciences, was published outside of Italy in Protestant Leiden. The work drew together much of Galileo's earlier efforts on the problem of motion; the second 'new science' (where Galileo, in retrospect, was less successful) dealt with the strength of materials.
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Perhaps the most important event in the history of science, the Principia lays out Newton's comprehensive model of the universe as organized according to the law of universal gravitation