Recombinant DNA technology and beyond

Madel and Higa

Mar 6, 1970

Madel and Higa were responsiblr for the first transformation of the beacterium escherichia coli

boyer and cohen

Mar 6, 1972

Cloning experiments were conducted Boyer and Cohen.

Genentech

Mar 6, 1973

Genentech, the world's first genetic engineering company. was founded

Paul berg

Mar 6, 1976

140 scientist met up to draw up guidelines for work with recombinant DNA in micoorganisms. Paul Berg was a key organizer.

Boyer

Mar 9, 1978

boyer inserted stnthetic insulin gene into E.coli

Botstein

Mar 9, 1978

Botstein found out that one could be identifeid by the pattern made of one's DNA thorough a digest by different enzymes. This DNA fingerprint was called Restriction Fragment Length Polymorphism.

Louise Joy Brown

Mar 9, 1978

Louise Joy Brown was born, the first human baby resulting from in vitro fertilixation, in which sperm and egg are joined in a petri dish. The fertilized egg is later implanted in a womb.

Biotech companies

Mar 9, 1980

The U.S.. Supreme Court ruked that genetically altered life forms can be patented. This resulted in a huge startup of biotech companies.

Transgenic animals

Mar 9, 1980

Ohio Univeristy scientist made the first transgenic animals.

Eli Lilly Company

Mar 9, 1982

Eli Lilly Company placed a human insulin gene inside bacteria.

Agrobacterium

Mar 9, 1983

Schell, Chilton, Can Montagu, Fraley, and Horsxh transformed with Agrobacterium-mediated gene transfer.

Jeffries

Mar 9, 1985

Jeffries applied RFLP and DNA profling to the study of criminal cases.

NIH

Mar 9, 1994

NIH revised safety guideline for recombinant DNA to include plants grown in greenhouses and animals raised in barns.

Fire and Mello

Mar 9, 1996

Andrew Fire and Craig Mello discovered RNA intefereence silencing of genes, in the worms C.elegans.

MAb

Mar 9, 1997

Kohler, Milstein, and Jerne used monoclonal antibody (MAb) technology.

YAC

Mar 9, 1997

Maynard Olson and colleagues at Washington Univeristy invented "Yeast artificial chromosomes," or YACS, which are expressions vectors for large proteins.

Wilmut

Mar 9, 1997

Ian Wilmut cloned Dolly the sheep from an adult cell of a ewe at the Roslin Institute in Scotland.

Ron Breaker

Mar 9, 2002

Ron Breaker coined the term riboswitch for a part of an mRNA molecule that can regukate its own activity and therefore gene expression.

HGP

Mar 9, 2003

Announcement was made of the completion of the Human Genome Project (initiated in 1990) by Francis Collins and Craig Venter. The project provided the ability to find genes and gave rise to the sequencing of other genomes