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The Powerpuff Girls series debut on November 18, 1998 was the highest rated premiere in Cartoon Network's history at the time. The series consistently scored the highest rating each week for the network across a wide range of demographics—from young children to adults.
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Award for Outstanding Individual Achievement in Animation[
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In October 2000, Cartoon Network credited the Powerpuff Girls for its Friday night prime time ratings win among cable networks.
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By the end of 2000, merchandising based on The Powerpuff Girls encompassed a whole variety of products, including T-shirts, toys, video games, lunchboxes, and dishware.
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Award for Outstanding Individual Achievement for Music Score an Animated Television Production
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Award for Outstanding Individual Achievement for Production Design in an Animated Television Production
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Award for Outstanding Individual Achievement in Animation
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In August 2008, McCracken revealed on his DeviantArt account, as had been announced in that year's Comic Con, that he was working with Cartoon Network on a new half-hour Powerpuff Girls special to celebrate the series' 10-year anniversary.
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The special, titled "The Powerpuff Girls Rule!!!", aired on the Pan-Euro Cartoon Network on November 29, 2008
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Powerpuff Girls Birthday Marathon in the United States on January 19, 2009, as part of its 10th anniversary marathon.