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Abraham Lincoln, who had declared "Government cannot endure permanently half slave, half free..." is elected president, the first Republican, receiving 180 of 303 possible electoral votes and 40 percent of the popular vote.
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South Carolina secedes from the Union. Followed within two months by Mississippi, Florida, Alabama, Georgia, Louisiana and Texas.
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The Confederate States of America is formed with Jefferson Davis, a West Point graduate and former U.S. Army officer, as president.
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President Lincoln issues a Proclamation calling for 75,000 militiamen, and summoning a special session of Congress for July 4.
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Virginia secedes from the Union, followed within five weeks by Arkansas, Tennessee, and North Carolina, thus forming an eleven state Confederacy with a population of 9 million, including nearly 4 million slaves. The Union will soon have 21 states and a population of over 20 million.
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President Lincoln appoints George B. McClellan as Commander of the Department of the Potomac, replacing McDowell.
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President Lincoln appoints McClellan as general-in-chief of all Union forces after the resignation of the aged Winfield Scott. Lincoln tells McClellan, "...the supreme command of the Army will entail a vast labor upon you." McClellan responds, "I can do it all."
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Victory for Gen. Ulysses S. Grant in Tennessee, capturing Fort Henry, and ten days later Fort Donelson. Grant earns the nickname "Unconditional Surrender" Grant.
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Gen. Robert E. Lee assumes command, replacing the wounded Johnston. Lee then renames his force the Army of Northern Virginia. McClellan is not impressed, saying Lee is "likely to be timid and irresolute in action."
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The president replaces McClellan with Gen. Ambrose E. Burnside as the new Commander of the Army of the Potomac. Lincoln had grown impatient with McClellan's slowness to follow up on the success at Antietam, even telling him, "If you don't want to use the army, I should like to borrow it for a while."