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After the Black Death left Italy, the Italian Renaissance began. Renaissance means, "New Birth".
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The Black Death had been literally plaguing everyone for years, and it finally ended, mostly. Bits of it are still around.
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The Gutenberg Press was an invention that used movable type. The letters could be moved around, multiple times, so that printing was a much easier and faster process. Many more people were able to read literature, creating a new age of knowledge.
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The Sistine Chapel was commisioned by Pope Sixtus IV. But Michelangelo only did the cieling, redoing what was once just gold stars on a blue background. Pope Julius II gave him free rein, and he re-did the entire cieling, making it the masterpiece it is today.
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The Last Supper depicted Jesus eating with his disciples before he was crucified. It was one of many paintings he created.
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The Renaissance, sadly, has come to an end. Yet most of the contributions made by the residents will stay.