Immune system By ryanw0721 2022 immunoglobulin E is an antibody and sometimes it mistakenly targets a certain protein found in food as a threat 2022 IgE can cause several chemicals to be released, the most important being histamine. 2022 histamine causes small blood vessels to expand 2022 the immune system goes into overdrive and releases large amounts of histamine 2022 affects the nerves in the skin, causing itching 2022 as a result a number of chemicals are released