- 
  
  
 - 
  
  
 - 
  
  
 - 
  
  
 - 
  
  Portuguese Admiral Albuquerque sets sail from Goa to Melaka.
 - 
  
  Albuquerque's forces take Melaka.
Sultan of Melaka escapes to Riau.
Portuguese in Melaka destroy a "Javanese" fleet. Their ship sinks with treasure on way back to Goa. - 
  
  Albuquerque sends three ships under da Breu from Melaka to explore eastwards.
 - 
  
  Da Breu expedition travels from Melaka to Madura, Bali, Lombok, Aru and Banda. Two ships are wrecked at Banda. Da Breu returns to Melaka; Francisco Serrão repairs ship and continues to Ambon, Ternate, and Tidore. Serrão offers support to Ternate in a dispute with Tidore--his men build a Portuguese post at Ternate.
 - 
  
  A force from Jepara and Palembang attacks the Portuguese in Melaka, but is repulsed. March Portuguese send an envoy to King of Pajajaran. Portuguese are allowed to build a fort at Sunda Kelapa (now Jakarta). Portuguese make contact with King Udara, son of Girindrawardhana and ruler over the remnant of Majapahit. Portuguese build factories at Ternate and Bacan. Udara attacks Demak with the help of the King of Klungkung on Bali. Majapahit forces are driven back, but Sunan Ngudung falls in bat
 - 
  
  Ali Mughayat Syah is first Sultan of Aceh
 - 
  
  First Portuguese visit Timor.
 - 
  
  Sultan Mahmud of Melaka takes power at Johore. Raden Patah passes away; Yunus becomes Sultan of Demak.
 - 
  
  Aceh begins taking northeast coast of Sumatra. Balinese attack on Lombok. Portuguese traders begin visiting Flores and Solor. Banjar on Kalimantan converts to Islam.
 - 
  
  Yunus leads fleet from Demak and Cirebon against the Portuguese in Melaka. Yunus is killed in battle. Trenggono becomes Sultan of Demak. Portuguese take Pasai in Sumatra; Gunungjati leaves Pasai for Mecca. Last ship of Magellan expedition around the world sails between Lembata and Pantar islands in Nusa Tenggara.
 - 
  
  February Portuguese expedition under De Brito arrives on Banda. May De Brito expedition arrives at Ternate, builds a Portuguese fort. Banten, still Hindu, asks for Portuguese help against Muslim Demak. Survivors of Magellan's expedition around the world visit Timor. Portuguese build fort at Hitu on Ambon.
 - 
  
  Gunungjati returns from Mecca and settles at Demak, marries sister of Sultan Trenggono.
 - 
  
  Treaty of Bungaya: Gowa submits to VOC control, and Sultan Hasanuddin has no influence outside the general area of the city of Makassar. VOC extends claims to Sumbawa and Flores after the defeat of Gowa. Bugis leaving the confusion on Sulawesi found Samarinda on Kalimantan. VOC builds a fort at Menggala in Lampung.
 - 
  
  Sultan Hasanuddin of Gowa passes away; continuing troubles against the VOC in Gowa finally end. VOC traders at Banjarmasin are massacred.