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460-370 BCE Herpes is formally recognized by Hippocrates as a "Creeping and Crawling" lesion.
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14 – 37 Emperor Tiberius Bans Kissing in the empire of Rome to prevent spread of the disease
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14 – 37 Roman Physician Celsus irons the sores to prevent spread.
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1500 – 1600 Shakespeare mentions herpes in Romeo and Juliet. It is descrivbed as oral sores given by the great fairy "Queen Mab"
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A book on herpes called “The Genital herpes” is published by French doctors Charles – Paul Diday and Adrien Doyon.
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Viruses are discovered by Dimitri Ivanski in Russia.
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French scientist Emile Vidal confirmed that herpes is a contagious skin condition and was transmitted from person to person.
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German Physician Paul Unna is able to tell herpes apart from syphilis
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Wilhelm Grater is able to develop the Grater Test, an effective method of diagnosing herpes untl the 1940s. Infected host is injected into the cornea of a rabbit and back into the infected host to determine illness.
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- Ernest Goodpasture is able to determine that herpes travels through the nerves instead of the blood.
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Frank Burnet determines that herpes can remain dormant in non-infected areas.
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Arnaud Tzanck develops cryto diagnosis, making the Grater test obsolete.
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The first anti viral drug is developed, Acylovir. 1978