gene therapy through the years...

By Jewcloudjazzjulia
  • Discovery of Gene Therapy

    Discovery of Gene Therapy

    Discovered that genes can be transfered from one organism to another.
  • Period: to

    gene therapy

  • Discovery of virus as a vector

    Discovery of virus as a vector

    Viruses can now be used to tranfer genes
  • First successful attempt of gene therapy

    First successful attempt of gene therapy

    Gene therapy was first attempted on a human
  • ADA defiency can be corrected in tissue culture

    ADA defiency can be corrected in tissue culture

    The laboratories in the National Heart, Lung, and Blood Institute and the National Cancer institute worked together to prove that cells with ADA defiency can be corrected in tissue culture. A retrovirus was used to carry the correct human ADA gene to the cells.
  • Gene therapy with animals.

    Gene therapy with animals.

    Drs. W. French Anderson and MIchael Blease and their team study the safety and effiency of correct genes that were transfered into bone marrow cells into animals. Although the process wasn't harmful, the number of cells that receieved the correct gene was too small to be useful.
  • Use of white blood cell

    Use of white blood cell

    The researchers decided to use white blood cells instead of bone marrow cells. This switch increased the number of correct genes taken up by the cells in the animal experiements. The success of these experiments led the researchers to start to look to due testing on people.
  • Gene therapy and cancer patients

    Gene therapy and cancer patients

    Steven Rosenberg worked with a team to grow tumor infiltrating lymphocytes (TIL cells) from people with the deadly cancer malignant melanoma and then they engineered a virus to put DNA marker into those cells. These "marked TIL cells" helped researchers which TIL cells work best for cancer treatment and that the engineered virus can be used safely in humans.
  • Girl wiht ADA Defiency

    Girl wiht ADA Defiency

    Drs. Anderson, Blease, and Kenneth Culver used a virus to deliver the correct ADA gene to a four-year old girl and a nine-year old girl with ADA Deficiency. Each girl was given repeated treatments over a period of two years.
  • Government funding

    Government funding

    Gene therapy researchers were granted $58M for their research by the United States government.
  • Newborns with ADA deficiency

    Newborns with ADA deficiency

    Researchers use gene therapy to treat newborn babies with ADA deficiency becasue their normal ADA genes were delivered to immature blood cells isolated from the babies' umbilical cord.
  • First death

    First death

    An 18 year-old boy named Jesse Gelsinger dies becasue the therapy did not succeed in curing is liver disease.
  • Continued research

    Continued research

    London Moorfields Eye Hospital has continued successful trials in curing blindness and failing eyesight.