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Oswald Avery's: Avery-MacLeod-McCarty Experiment
In the Avery-MacLeod-McCarty experiment, these there biochemists comfirmed the "Transforming Principle: a substance that could cause a heritable (transmissible change form a parent to an offspring) change of bacteria cells. He also used proccess of elimination to identify the "transforming principle". He found a way to make the DNA fight viruses. The Transforming Principle stated that DNA had the capability to transform properities in the cell. -
Oswald Avery's: Avery-MacLeod-McCarty experiment (continued)
Without Oswald Avery's discovery of the "transforming principle" of DNA scientists would not be able to know how DNA has the capability to transform particles in the cell and would not know DNA's true meaning. -
Rosalind Franklin
Rosalind Frank was known for many discoveries. She was a crysallographer (a person who determines the arrangements of atoms). Frank used xrays difraction images to view DNA at a close spectrum, and be able to see the double helix. She also found that their are two forms of DNA depending on the relative humidity in the air. Without Franklin's discovery, we would not know the phosphate was on the outside of the double helix and the shape of the double helix. -
Erwin Chargaff
Erwin Chargaff managed to make a set of rules known as "Chargaff's rules". His rules stated; that every cell must have a 1:1 ratio of pyrimidine, and purine. His discovery said that certain bases must always pair with another base. Here are the combinations: Guanine (Purine) always pairs with Cytosine (Pyrimidine) and Adenine (Purine) always pairs with Thymine (Pyrimidine). -
Erwin Chargaff (Continued)
Without his discovery and addition to the science community we would not understand bases, and how during DNA replication even though the double helix splits in half, it can still make an exact replication -
Watson and Crick's: DNA structure model
In 1953, Watson and Crick described the structure of DNA and made a model representation of the double-helix. Using past scientist research and experiments,(like Oswald Avery, Erwin Chargaff and Rosalind Franklin) these two scientists pieced together the data and known information about the double helix structure. They used Erwin Chargaff research on the pairing of the bases, Rosalind Franklin's xray diffraction images to help decide the shape of the DNA and what the location of the phosphates.
