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In this battle, the Union realized that the Confederacy wasn't a joke and that it would be a long and difficult war.
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Antietam was the bloodiest battle of the Civil War, in which 23,000 men died in battle.
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Gettysburg is the most famous battle of Civil War. It is seen as one of the turning points in the war, as the Confederacy took a crippling loss.
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Appomattox is the location where General Lee surrendered, which is also what is generally know as the event that ended the Civil War.