First black slaves in America brought to Spanish colony of Santo Domingo.
Apr 4, 1503
Leonardo da Vinci paints the Mona Lisa
Apr 4, 1524
Verrazano, sailing under the French flag, explores the New England coast and New York Bay.
Apr 4, 1527
Troops of the Holy Roman Empire attack Rome, imprison Pope Clement VII—the end of the Italian Renaissance. Castiglione writes The Courtier. The Medici family expelled from Florence.
Apr 4, 1582
Pope Gregory XIII implements the Gregorian calendar
Miguel de Cervantes's Don Quixote de la Mancha, the first modern novel.
Jamestown, Virginia, established-first permanent English colony on American mainland. Pocahontas, daughter of Chief Powhatan, saves life of John Smith.
Pilgrims from England arrive at Plymouth, Massachusetts, on the Mayflower.
In Massachusetts, the general court approves a law that makes religious heresy punishable by death.
The English monarchy is restored under King Charles II.
January 17, Benjamin Franklin is born in Boston. In November, South Carolina establishes the Anglican Church as its official church.
Hostilities break out between Native Americans and settlers in North Carolina after the massacre of settlers there. The conflict, known as the Tuscarora Indian War will last two years
