Progress in Research and Development of Grafts

By gautam.tammewar
  • Period: to

    Important Papers in the Development of the Graft

  • Endothelial cell seeding of PTFE vascular grafts in humans

    Endothelial cells were seeded into the lumen of the graft. Though the endothelial cell lining of the graft decreases the thrombogenicity of the graft, immune response to grafts still remain. Zilla P et al. Endothelial cell seeding of PTFE vascular grafts in humans: a preliminary report. J Vasc Surg. 1987 Dec;6(6):535-41.

  • Autocrine angiogenic vascular prosthesis with bone marrow transplantation

    ePTE vascular grafts were infiltrated with marrow cells and were implanted in the abdominal aortic position of 24 dogs autologously. Noishiki Y, Tomizawa Y, Yamane Y, Matsumoto A. Autocrine angiogenis vascular prosthesis with bone marrow transplantation. Nat Med. 1996;2:90-3.

  • Novel vascular graft grown within recipient's own peritoneal cavity

    Silastic tubing was inserted into the peritoneal cavity of rats or rabbits, and by 2 wks, were covered by layers of collagen matrix and myofibroblasts. This silastic tubing was explanted and the tube everted. The transplant remained patent for 4 months.The graft was an autologous transplantation used for end to end anastomosis into the transected abdominal aorta- carotid artery. Campbell JH et al. Novelvascular graft grown within recipient's own peritoneal cavity. Circ Res. 1999 Dec 3-17;85(12)

  • Creation of a functional tissue-engineered blood vessel (TEBV)

    Autologous bone marrow cells were seeded into a porous biodegradable scaffold composed of copolymer of L-lactide and -caprolactone (50:50). The graft was used to recconstruct the pulmonary artery. This implantation was not tested in a high pressure vascular system. Shin'oka T et al. Transplantation of a tissue-engineered pulmonary artery. N Engl J Med. 2001;344:532-3

  • Dog peritoneal and pleural cavities as bioreactors to grow autologous vascular grafts

    Bare tubing or tubing wrapped in Dexon or Prolene mesh were inserted into the peritoneal cavity or pleural cavity of dogs. After three weeks, the tubes and tissue were removed and the inner tubing was discarded. Autologous tranplantation of 11 tissue tubes were done as interposition grafts into the femoral artery.

  • Goes with the Chue WL of same date.

    The biodegradable mesh disappeared in three months. Chue WL, et al. Dog peritoneal and pleural cavities as bioreactors to grow autologous vascular grafts. J Vasc Surg. 2004 Apr; 39 (4):859-67.

  • Midterm clinical result of tissue-engineered vascular autografts seeded with autologous bone marrow cells.

    Tissue-engineered vascular autografts seeded with autologous bone marrow cells were implanted in humans. Shin'oka et al. Midterm clinical result of tissue-engineered vascular autografts seeded with autologous bone marrow cells. J Thorac Cardiovasc Surg. 2005 Jun;129(6):1330-8.

  • Human tissue-engineered blood vessels for adult arterial revascularization

    Tissue engineered blood vessels were constructed from adult human fibroblasts extracted from skin biopsies of human subjects with advanced cardiovascular disease. L'Heureux et al. Human tissue-engineered blood vessels for adult arterial revascularization. Nat Med. 2006 Mar;12(3):361-5. Epub 2006 Feb 19.

  • Development of the wing-attached rod for acceleration of "Biotube" vascular grafts fabrication in vivo

    These Biotubes were not implanted and therefore its performance is unknowns Sakai O, Nakayama Y. Development of the wing-attached rod for acceleration of "Biotube" vascular grafts gabrication in vivo. J Biomed Mater Res B Appl Biomater. 2007 Oct; 83(1):240-7.

  • Development of a tissue-engineered vascular graft combining a biodegradable scaffold, muscle-derived stem cells and a rotational vaccuum seeding technique

    Nieponice and Vorp developed a vaccuum seeding device that seeded muscle-derived stem cells into a tubular polyester urethane urea scaffold. The graft was developed in a week with adequate mechanical strenght, but was not implanted. Nieponice A, Soletti L, Guan J, Deasy BM, Huard J, Wagner WR, et al. Development of a tissue-engineered vascular graft combining a biodegradable scaffold, muscle-derived stem cells and a rotational vaccuum seeding technique. Biomaterials 2008;29:825-33.

  • Faster and stronger vascular "Biotube" graft fabrication in vivo using a novel nicotine-containing mold

    The Biotube was impregnated with nicotine and embedded into subcutaneous pouches of rats. In two weeks, Biotubes had 3.8 times as many neovessels as the uncoated controls. These vessels were not implanted in humans and performance in human subjects is unknown. Sakai O, Nakayama Y, et al. Faster and stronger vascular "Biotube" graft fabrication in vivo using a novel nicotine-containing mold. J Biomed Mater Res B Appl biomater. 2009 Jul;90(1)412-20.

  • Effectiveness of haemodialysis access with an autologous tissue-engineered vascular graft: a multicentre cohort study

    The first multicenter trial in dialysis patients in which TEVG was tested. 10 Hemodialysis patients were enrolled from centers in Argentina and Poland. Completely autologous tissue-engineered vascular grafts were grown in culture supplemented with bovine serum and implanted as AV shunts. McAllister et al. Effectiveness of haemodialysis access with an autologous tissue-engineered vascular graft: a multicentre cohort study. Lancet. 2009 Apr 25;373(9673):1440-6.

  • Creation of biodegradable bilayered elastomeric scaffold

    The graft was made of two layers. The outside layer was fibrous to provide mechanical strength; The inside layer was made porous. The graft was seeded with muscle-derived stem cells. This graft was not implanted in large animals or human subjects. Soletti L et al. A bilayered elastomeric scaffold for tissue engineering of small diameter vascular grafts. Acta Biomater. 2010 Jan;6(1):110-22