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Period: to
Doodey
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1st free living organism
First free living organism to be sequenced -
Thomas Hunt Morgan
He proved hetretitary in fruit flys. -
Alfred Sturtevant
Sturtevant constructed the first genetic map of a chromosome in 1913. -
Jean Brachet
In 1933 Brachet was able to show that DNA was found in chromosomes and that RNA was present in the cytoplasm of all cells[1]. His work with Torbjörn Caspersson showed that RNA plays an active role in protein synthesis. Brachet also carried out pioneering work in the field of cell differentiation. Brachet later demonstrated papers that differentiation is preceded by the formation of new ribosomes and accompanied by the release from the nucleus of a wave of new messenger RNA. -
Beadle and Tatum
Beadle and Tatum's key experiments involved exposing the bread mold Neurospora crassa to x-rays, causing mutations. In a series of experiments, they showed that these mutations caused changes in specific enzymes involved in metabolic pathways. These experiments led them to propose a direct link between genes and enzymatic reactions, known as the "one gene, one enzyme" hypothesis. -
Tjio & Levan Albert
Albert Levan is best known today for co-authoring the report in 1956 that humans had forty-six chromosomes (instead of forty-eight, as previously believed). This epochal discovery was made by Joe Hin Tjio in Levan's laboratory. Now Tjio knew "the chromosome number of man" was 46. Tjio's revolutionary finding was published (with Levan as his co-author) in the Scandinavian journal Hereditas on January 26, 1956, only a month and four days after the discovery. -
Meselson–Stahl experiment
DNA replication was semiconservative. Semiconservative replication means that when the double stranded DNA helix was replicated, each of the two double stranded DNA helices consisted of one strand coming from the original helix and one newly synthesized. It has been called "the most beautiful experiment in biology -
Sanger Fred
Sanger's first triumph was to determine the complete amino acid sequence of the two polypeptide chains of insulin in 1955. Prior to this it was widely assumed that proteins were somewhat amorphous. In determining these sequences, Sanger proved that proteins have a defined chemical composition. For this purpose he used the "Sanger Reagent", fluorodinitrobenzene (FDNB), to react with the exposed amino groups in the protein and in particular with the N-terminal amino group at one end of the polypep -
Howard Martin Temin
Temin's description of how tumor viruses act on the genetic material of the cell through reverse transcription was revolutionary. This upset the widely held belief at the time of the "Central Dogma" of molecular biology posited by Nobel laureate Francis Crick, one of the co-discoverers of the structure of DNA (along with James Watson and Rosalind Franklin). -
1st DNA based genome
DNA based genome completed -
Fiers Walter
His research involved Bacteriophage MS2; he was the first to establish the complete nucleotide sequence of a gene (1972) and of a viral genome (bacteriophage MS2)(1976). In 1978 Fiers and his team were the first to reveal the complete nucleotide-sequence of SV40. The development of totally new procedures and knowledge led to the ability to clone almost any gene and to express these efficiently in bacteria or in other heterologous hosts. -
1st complete sequence of bactriopaghe
Its completed -
1st sequence of a gene
They sequenced a strand of DNA. -
1st gene of sequence
Fred Sanger -
Yeast Genome
We gots d yeast Genome now -
Drosophila
Drosophila genome -
Mouse
Mouse genome -
C. Elegant genome
Multi cellular organism to have it genome sequenced -
HGP completed
The Human Genome Project (HGP) was an international scientific research project with a primary goal to determine the sequence of chemical base pairs which make up DNA and to identify and map the approximately 20,000–25,000 genes of the human genome from both a physical and functional standpoint. -
Arabidaptids genome
First plant to be entirly sequenced -
Dog genome
Doggy genome -
Chimp Genome
The Chimpanzee Genome Project is an effort to determine the DNA sequence of the Chimpanzee genome. It is expected that by comparing the genomes of humans and other apes, it will be possible to better understand what makes humans distinct from other species. -
Brown
Brown Rat genome -
Zebra fish
Zebra fish genome -
Fredrick Griffith
What is now known today as Griffith's experiment, he discovered what he called a transforming principle, which led to the direct discovery of how DNA works and the beginning of Molecular Genetics.[1][2] All modern molecular biology has evolved from this discovery.