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If Friedrich Sertûrner hadn't discovered the Morphine; many sick people would have suffered from terrible pain for long time.
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If Samuel Morse hadn't improved the telegraph into the electro-magnetic telegraph and hadn't created the morse code; there wouldn't have been a revolution in communications, therefore telephone, radio, television and internet would have been a dream.
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If Alexander Graham Bell hadn't invented the telephone; it would have been difficult for people to communicate with others quickly.
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If Wilhelm Conrad Rontgen hadn't discovered the X-rays; in medicine it would have been difficult to identify fractures and hidden diseases in human beings and animals.
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If Orville and Wilbur Wright hadn't invented the first modern wing aircraft; mankind wouldn't have been able to cross continents and countries in a short time.
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If the USA, Britain and Canada hadn't developed the first atomic bomb; many people wouldn't have died in Hiroshima and Nagasaki.
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If John Bardeen and Walter Brattain hadn't invented the transistor, there wouldn't have been a revolution in computers, controls,and communicaction
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If Gerald Pearson, Calvin Fuller and Daryl Chapin hadn't invented the solar battery; it would have been difficult to collect energy from sun and turn it into a current of electricity to help poor families to access to electricity and improve their life quality.
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If Vinton Cerf and Robert E. Kahn hadn't invented the internet protocol suite, mankind would have been for long using typewriters, postcards and letters to communicate. Businesses, schools and homes wouldn't have progress in the way they are nowadays.
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If Sui Dynasty hadn't invented the toilet paper; it would have been awkward for people to go the restroom for the rest of their lives.