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Pilgrims establish Plymouth Colony, marking the beginning of European settlement in New England.
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Salem Witch Trials highlight issues of religious intolerance and social hysteria.
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French and Indian War sets the stage for increased tensions between the American colonies and Britain.
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Declaration of Independence is adopted, signaling the start of the American Revolutionary War.
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U.S. Constitution is drafted, establishing the framework for the federal government.
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Eli Whitney invents the cotton gin, revolutionizing cotton production and slavery.
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Louisiana Purchase doubles the size of the United States.
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American Civil War over issues of slavery and states' rights.
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Emancipation Proclamation declares slaves in Confederate states to be free.
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First Transcontinental Railroad completed, connecting the East and West coasts.
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Spanish-American War leads to the acquisition of Puerto Rico, Guam, and the Philippines.
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United States enters World War I.
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19th Amendment grants women the right to vote.
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Stock market crash triggers the Great Depression.
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United States enters World War II after the attack on Pearl Harbor.
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Civil Rights Movement challenges racial segregation and inequality.
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Apollo 11 successfully lands astronauts on the moon.
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Terrorist attacks on September 11 prompt the War on Terror and homeland security changes.
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Financial crisis leads to the Great Recession.
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Affordable Care Act (Obamacare) is signed into law, aiming to reform the healthcare system.