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Che Guevara and his friend Alberto start their journey to North America for 8 months after hopping on an old motorcycle.
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Che and Alberto go to Piedra del Águila, Argentina so Che can visit his lady-friend who goes by the name Chichina.
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A local newspaper writes about Che and Alberto discussing their experience and qualifications as medical doctors.
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Che receives a letter from his lady-friend, Chichina. Although he doesn't read it out loud, he receives bad news.
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At nightfall they camp with a family who lost their farm.
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Alberto suggests that he and Ernesto start a domestic party to carry on the revolution of Tupac Amaru.
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Pesce gives Che and Alberto clothes with a ticket for the Amazon River ferry. Che has an asthma attack while on the ferry.
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Che and Alberto go to a dance party at the colony and Alberto dances with a nun and Che dances with a pretty woman.
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Che decides he wants to celebrate his birthday on the other side of the Amazon River with patients but the boat is on the other side so Che jumps in the river Alberto tells him to get out so he doesn't get eaten by the animals living in the river.
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Che tells Alberto that something has changed him during the trip and notices the kindness of others throughout the trip. They hug and part.