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George tells Lennie to get rid of the dead mouse. Lennie just likes to pet soft things.
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George gives Lennie the "ok" to defend himself and crushes Curley's hand when he stops it from hitting him again.
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Lennie is given a puppy, but he accidentally kills it because he "bounced it too hard".
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Curley's wife tries to get Lennie to touch her soft dress, but he panicked, she screamed, and in his confusion, he shook Curley's wife too hard.
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George knows that Lennie will be lynched for what he has done. He doesn't think there is any other choice for a peaceful death for Lennie. So, he takes his life before it is taken from him.