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She was born in Jefferson City, Missouri
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As a junior in 2005–06, she was named the Naismith Prep Player of the Year after leading Collins Hill High School to Georgia's Class 5A state championship
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She led the Collins Hill Eagles over Poly (Long Beach, California) by a score of 75–61, resulting in her being selected unanimously as the Most Valuable Player of the Tournament of Champions in Chandler, Arizona.
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Moore became Collins Hill High School's all-time leader in points and rebounds. During her four seasons at Collins Hill, the school amassed a 125–3 record. Moore won 3 Georgia Class 5A State Championships.
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She was selected as the John Wooden Award winner in 2009 after leading Connecticut to the undefeated national championship.
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The following season, Moore led Connecticut to its second straight national championship and continued its overall undefeated streak at 78
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On May 18, 2011, Moore became the first female basketball player to sign with Jordan Brand
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In 2012, Moore helped the Lynx begin the season with a 10-0 run, the best start in WNBA history.
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