Major Advances in Human Cancer Epigenetics

  • Altered gene methylation in cancer

  • Universality of epigenetic changes in human cancer

  • CpG-cluster methylation marks inactive promoters on inactive X-chromosome

  • Hypermethylation of calcitonin

  • Parent-of-origin-specific loss of heterozygosity in tumours

  • Hypermethylation of a tumour-suppressed gene

  • Promoter methylation enforces gene silencing on the inactive X chromosome

  • Human trithorax is a proto-oncogene

  • Insulin-like growth factor-2 loss of imprinting in cancer

  • Several epigenetic detects linked to Beckwith-Wiedemann syndrome

  • Functional association between epigenetics and tumour suppression

  • Histone deacetylation in X inactivation

  • Gatekeeper role for epigenetic alterations in cancer

  • Retinoblastoma tumour-suppressor genes sets epigenetic states in SWI/SNF complex

  • Mouse model for cancer epigenetics

  • Frequent tumour suppression gene methylation in cancer

  • Chromatin-remodeling complex mutated in human cancers

  • DNA hypomethylation linked to chromosomal instability

  • Epigenotype-phenotype analysis shows gatekeeper role in human cancer system

  • Altered histone lysine methylation at silenced tumour supressor loci

  • Renaissance of hypomethylation and gene activation in cancer

  • Polycomb proteins hypothesized to account for gene silencing in cancer

  • DNA hypomethylation linked to environmental toxins and diet

  • Clinical trials of 5 aza 2 deoxycytidine and trichostain A therapy in cancer patients