Major Advances in Human Cancer Epigenetics By minhitmaid Mar 27, 1983 Altered gene methylation in cancer Mar 27, 1985 Universality of epigenetic changes in human cancer Mar 27, 1985 CpG-cluster methylation marks inactive promoters on inactive X-chromosome Mar 27, 1986 Hypermethylation of calcitonin Mar 27, 1987 Parent-of-origin-specific loss of heterozygosity in tumours Mar 27, 1989 Hypermethylation of a tumour-suppressed gene Mar 27, 1990 Promoter methylation enforces gene silencing on the inactive X chromosome Mar 27, 1992 Human trithorax is a proto-oncogene Mar 27, 1993 Insulin-like growth factor-2 loss of imprinting in cancer Mar 27, 1993 Several epigenetic detects linked to Beckwith-Wiedemann syndrome Mar 27, 1993 Functional association between epigenetics and tumour suppression Mar 27, 1993 Histone deacetylation in X inactivation Mar 27, 1994 Gatekeeper role for epigenetic alterations in cancer Mar 27, 1994 Retinoblastoma tumour-suppressor genes sets epigenetic states in SWI/SNF complex Mar 27, 1995 Mouse model for cancer epigenetics Mar 27, 1997 Frequent tumour suppression gene methylation in cancer Mar 27, 1998 Chromatin-remodeling complex mutated in human cancers Mar 27, 1999 DNA hypomethylation linked to chromosomal instability Mar 27, 2001 Epigenotype-phenotype analysis shows gatekeeper role in human cancer system Mar 27, 2002 Altered histone lysine methylation at silenced tumour supressor loci Mar 27, 2002 Renaissance of hypomethylation and gene activation in cancer Mar 27, 2002 Polycomb proteins hypothesized to account for gene silencing in cancer Mar 27, 2003 DNA hypomethylation linked to environmental toxins and diet Mar 27, 2003 Clinical trials of 5 aza 2 deoxycytidine and trichostain A therapy in cancer patients